CBD vs THC – What is the Difference? How CBD and THC Work in the Body by Thomas DeLauer

ARE CBD & THC THE SAME? CBD (cannabidiol) and THC (tetrahydrocannabinol) often get lumped together because they both are derived from hemp and are used therapeutically. But are they the same?
Thomas DeLauer discusses what makes CBD and THC different.
CBD and THC do different things in your body. They both ultimately act upon what are called CB1 and CB2 receptors in the body, but what’s interesting is that CBD doesn’t even directly affect those receptors. I’ll make some sense of all this in just a second, but first off, let me just quickly explain what CBD is.

CBD is usually an oil that’s derived from maybe hemp or some other cannabis compound. What the whole purpose of CBD is, is to give you the non-psychoactive components of cannabis but with all the positive effects, but what we have to look at is that it really acts in a whole different system in the body.

We have something in our bodies known as endocannabinoids. Endocannabinoids are our body’s own natural way of stimulating the CB1 and CB2 receptors, basically to modulate inflammation or to modulate our nervous system or to really have different effects in the body. The CB1 receptors directly affect our brain and directly affect our nervous system, whereas the CB2 receptors directly affect our immune system.

But the interesting thing is, is that CBD oil doesn’t actually affect these at all. What it does is it stimulates the production of our body’s natural endocannabinoids, and it slightly changes the structure of the CB1 and CB2 receptors. It allows your body to naturally create more of these endocannabinoids, whereas cannabis, you’re directly putting a compound in your body that’s going to directly affect these receptors.

When you consume THC, or cannabis, that THC directly stimulates the CB1. It directly affects it. It binds with it perfectly, and it affects it, and it stimulates it, which is why you get the nervous system response and why you get the psychotropic response. There’s very little stimulation or very little effect on the actual CB2 receptors. There is a little bit, so you do get some immune response, but most of it is psychological. Most of it is nervous system related. That’s why you end up getting pain relief. That’s why you end up getting the effects that are going to help you feel better, simply because you’re stimulating that CB1 receptor.

Then we look at CBD oil, which directly affects the CB1 receptor in an entirely different way. It changes the CB1’s actual structure. It makes it more receptive to endocannabinoids. If you look at this one receptor that THC or cannabis usually stimulates, whenever you take CBD, it changes that structure. It makes it more enticing to your body’s natural endocannabinoids.

We’re talking about anandamide, all these natural things that just help you feel good and feel relaxed and feel just a general sense of well-being. When you change that structure, you’re making it more receptive to that, but what you’re also doing is you’re making it less receptive to THC. A lot of times, what people will do is they will actually combine CBD with THC because CBD blocks the ability for THC to really have that much of an effect.

Basically, THC makes you high. CBD doesn’t. In fact, CBD stops you from getting high. When you actually look at the difference between CBD and THC, people will always say that they’re so similar and, “Oh, it’s like a legal form of THC, or a legal form of cannabis.” It’s actually the anti-cannabis in a way. It’s like the anti-THC. It’s the other side of the equation that stimulates your body’s natural production of these endocannabinoids and allows your body to use them naturally.

What is CBD and CBD Oil? https://youtu.be/CwN-LByRLcw
Does CBD Help Anxiety and Depression? https://youtu.be/Hvx3qbwao_4
Does CBD Stop Pain? https://youtu.be/PbnrRoceybk
Is CBD Effective? https://youtu.be/DclklTCuCAg
Does CBD Help You Sleep Better? https://youtu.be/0GAscp_akTY


42 thoughts on “CBD vs THC – What is the Difference? How CBD and THC Work in the Body by Thomas DeLauer

  1. If you strip all the THC from the bud and plant, of the female cannabis plant and leave only the CBD content is there any difference to only using CBD from the hemp ( male ) full plant. ie no bud and not female plant.

    I am continually having this conversation with a few family members.

    I’m wanting CBD for Arthritis and inflammation and am being told that I’m wasting my money on the hemp only CBD.

    So I suppose my question is, is full spectrum hemp cbd as strong acting as cannabis cbd – remembering I’m not talking about THC.

    Thanks in advance for your advice

  2. Edit –

    I'm sorry, but after a week of smoking CBD flower i feel like shit. There's no way I could smoke this shit like weed. I developed a cough in just a few days. I even felt tired like when I used to smoke weed, except in this case I had more of a headache everytime I smoked. I'm talking after an hour or more I'd brush it off, but nope it'd linger all day.

  3. What about doing a video on CBN? This is something new, so any information or more importantly testimony would be greatly appreciated:) it's basically cannabis oil with 10mg thc and 10mg cbn? Alien Dawg is the strain the oil came from. It does have 0 – 0.7mg cbd

  4. Look, all I know is this. I tried CBD oil without the THC, (two different brands) and one with a slight amount of THC. Guess which one was more effective? Yep. The one with THC. Now, I don't know how much is too much, or whatever, but I know it's helped my general mood, and seems to be more effective with my lower back pain and some nueropathy as a result of a bad back. So…I don't know what to make of it, but it's called full spectrum oil and it works.

  5. CBD does not prevent you from getting high, it modulates how intense that high will be. I use a <1% THC, 14% CBD flower, I still feel the effects of the THC, although mildly. However, if I smoke 2 joints of that,. I can then hit dabs all night long without greening out…It's almost like I'm invincible to weed, I still get baked but it's almost like the CBD just prevents me from getting higher than I should despite how much I smoke. It's very strange. Great video btw.

  6. Thanks for the information! I just decided to write about the FDA hearing on CBD for a college assignment and realized I didn't know enough about the difference between CBD and THC. This was very helpful.

  7. This video does not clear up misunderstandings between cannabis, hemp and marijuana despite technical language used.
    It’s simple:
    Cannabis with more than 0.3% THC = marijuana strain of cannabis.
    Cannabis with less than 0.3% THC = hemp strain of cannabis.
    Both hemp and marijuana are cannabis.
    It’s the amount of psychoactive THC within the cannabis plant which determines whether it is marijuana (gets you high) or whether it is hemp (does not get you high).
    CBD is present in both strains.

  8. I watched so many other useless videos but it was worth it because I found this one. Very informational, right to the point. I'm going to take LEGIT notes on this so I could explain to those around me who don't know the difference.

  9. I would like to know your source's of info and data, I have always liked how you explain everything but is there some kind of new research study out from neurologists or doctors that we don't know about? The science behind cbd from a full hemp plant has always been choppy with who to believe and who not to believe scientifically speaking.

  10. I think I see why you describe THC as more of a drug (if it affects the receptors itself, directly, but you are ignoring the considerable (if still anecdotal, though this is also the case with CBD) medicinal effects of THC, especially in its form as an extracted oil (as in, for example, Rick Simpson Oil). THC seems to be as much a medicine as CBD, addressing a different range of health issues.

  11. Great video: so your saying CBD is like a THC blocker? So is the CBD oil that is THC Free better for you?
    My reason for asking is, I am a veteran and now work as a LEO. So we are drug tested.
    Do you know if Full Spectrum CBD oil will give a Positive reading for THC?
    Thank you,

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